LDL is Dead. Oxidation is the Killer.

Cholesterol isn’t the fuse. It’s the fire alarm.

We didn’t build OXO to track LDL. We built it to measure collapse — before it shows up in a lipid panel.

And the deeper we went, the clearer it became: oxidized linoleic acid metabolites are the real killers.

🧬 Meet the Molecules That Actually Break You

• 4-Hydroxynonenal (4-HNE) – lipid peroxidation’s most toxic aldehyde
• 9-HODE, 13-HODE – oxidized omega-6 markers tied to atherosclerotic plaque instability
• MDA – a reactive aldehyde elevated in patients post-myocardial infarction

These aren’t fringe biomarkers. They’re the causal agents behind endothelial dysfunction, mitochondrial collapse, and silent inflammatory damage.

🧨 LDL Has Been Misused Since the Framingham Study

LDL-C became the scapegoat because it was easy to measure and easy to lower with a pill.

But it’s not predictive.

75% of people hospitalized with heart attacks have normal LDL levels.

Meanwhile, oxidative stress biomarkers like 4-HNE rise years before the event. Yet they’re never measured.

Until now.

🧠 Statins Don’t Fix the Fire

Lowering LDL doesn’t touch the oxidative cascade:

• It doesn’t reduce 4-HNE
• It doesn’t improve mitochondrial resiliency
• It doesn’t change the toxic burden from seed oils

This is why “residual risk” still kills patients — despite their LDL being "under control."

🔥 The Real Collapse Predictor

We don’t care how much cholesterol you have floating around. We care how much damage it’s taking — and what’s breaking downstream.

That’s what the OXO Score measures.

• Oxidation load
• Detox depletion (e.g. glutathione)
• DNA & mitochondrial stress

LDL was never the killer. It was the distraction.

🧭 The Shift Has Already Started

Researchers like Ramsden, DiNicolantonio, and Halliwell have been pointing at this for years.

We’re just making it testable, trackable, and actionable — at scale.

Want to know your real risk? Run your OXO Score.